Specimen:

CSF

Collection Medium:

Minimum:

Preferred minimum: TWO 1 mL aliquot CSF
Absolute minimum: TWO 0.5 mL aliquot CSF

Rejection Criteria:

Grossly bloody or hemolyzed specimens.

Analytic Time:

1 week

Reference Range:

       Component Name                  Reference Range
Coccidioides Antibody by CF:                < 1:2

Coccidioides Antibody by ID:            None detected

Coccidioides Antibody, IgG by ELISA:
                                       0.9 IV or less = Negative
  Negative-No significant level of Coccidioides IgG antibody detected.
                                       1.0-1.4 IV = Equivocal
  Equivocal-Questionable presence of Coccidioides IgG antibody
  detected.  Repeat testing in 10-14 days may be helpful
                                       1.5 IV or greater = Positive
  Positive-Presence of IgG antibody to Coccidioides detected,
  suggestive of current or past infection.

Coccidioides Antibody, IgM by ELISA:   0.9 IV or less = Negative
  Negative-No significant level of Coccidioides IgM antibody detected.
                                       1.0-1.4 IV = Equivocal
  Equivocal-Questionable presence of Coccidioides IgM antibody
  detected.  Repeat testing in 10-14 days may be helpful.
                                       1.5 IV or greater = Positive
  Positive-Presence of IgM antibody to Coccidioides detected,
  suggestive of current or recent infection.

Test
Limitations:

Note:
Antibody in CSF is considered diagnostic for coccidioidal meningitis, 
although 10% of patients with coccidioidal meningitis will not have 
antibody in CSF.  Negative fungal serology does not rule out the 
possibility of current infection.

Methodology:

Complement Fixation (CF)
Immunodiffusion (ID)
Enzyme-Linked Immunosorbent Assay (EIA)

CPT Code:

86635 Cocci Ab (CF)
86635 Cocci Ab (ID)
86635 Cocci IgG (EIA)
86635 Cocci IgM (EIA)

See also:
Aspergillus Antibody by ID, Serum
Blastomyces Antibody by ID, Serum
Coccidioides Antibodies by CF, ID, ELISA, Serum
Fungal Serology, Serum
Histoplasma Antibodies CF, ID, Serum