The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK

Keppra (Levetiracetam)
Order Code: KEPPRA
Order Form: A-1a Miscellaneous Request or IPR Req 		  Commercial "Mail-out" Laboratory
6240 RCP
356-3527 
Specimen
 
Serum or Plasma
Collection Medium:
Red top tube 


Alternate
Collection Media:


Lavender top tube (EDTA), Pink top tube (EDTA sprayed), Green top tube 
(Na Heparin)


Minimum:


Preferred minimum: 2 mL serum or plasma
Absolute minimum: 0.8 mL serum or plasma


Analytic Time:


4 days


Reference Range:


Therapeutic range: Not well established


Comments:


The proposed therapeutic range for seizure control is 5-30 mcg/mL. 
Pharmacokinetics of levetiracetam are affected by renal function. The 
relationship between serum concentrations and toxicity is not known.


Methodology:


High Performance Liquid Chromatography


CPT Code:


80299




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Updated: 05/22/2007

Note: The information contained in this handbook is  
            for use by personnel of University of Iowa Health Care. 
            No other use is implied or intended.