Specimen:

Plasma

Collection Medium:

Alternate
Collection Media:

Call laboratory for additional acceptable specimen collection 
containers.

Minimum:

2 mls whole blood in light green top tube or one microtube for 
pediatric patients

Testing Schedule:

24 hrs/day, 7 days a week, including holidays.

Analytic Time:

2 hours (upon receipt in laboratory)

Reference Range:

Confirm 3.4-7.0 mg/dl (males) and 2.4-5.7 mg/dl (females)

Pediatric Reference Ranges:

Age          Range    Units
0-2 years    2.0-7.0  mg/dl
2-12 years   2.0-6.5  mg/dl
12-14 years  2.0-7.0  mg/dl

Comments:

Patients on rusburicase (Elitek) please see additional information 
listed in the link below.

Test
Limitations:

Criterion: Recovery within plus or minus 10% of initial values

Plasma
Icterus: No significant interference up to an I index of 40 
(approximate conjugated and unconjugated bilirubin concentration 40 
mg/dl or 684 umol/l).

Hemolysis: No significant interference up to an H index of 1000 
(approximate hemoglobin concentration: 1000 mg/dl or 621 umol/l).

Lipemia (Intralipid): No significant interference up to an L index of 
1000 (approximate triglycerides concentration: 2000 mg/dl or 22.8 
mmol/l).

There is poor correlation between turbidity and triglycerides 
concentration.

Ascorbic acid less than 30 mg/dl does not interfere.

Of the drugs tested in vitro, o-methyldopa, desferoxamine and 
calciumdobesilate (e.g. Dexium) cause interference at therapeutic 
concentrations (uric acid level artificially low).

Uricase reacts specifically with uric acid. Other purine derivatives 
can inhibit the uric acid reaction.

Reference:
Glick MR, Ryder KW, Jackson SA. Graphical Comparisons of Interferences 
in Clinical Chemistry Instrumentation. Clin Chem 1986;32:470-474.

Methodology:

Enzymatic

CPT Code:

84550

See also:
Uric Acid (patients on rasburicase), Plasma

See Additional Information:
Chemistry Pediatric Reference Ranges