The University of Iowa (UIHC)
Department of Pathology
LABORATORY SERVICES HANDBOOK


Narcolepsy - HLA DNA Panel
Order Code: NARC
Epic Lab Code: LAB3685
Order Form: A-1a Miscellaneous Request or Epic Req
  Commercial "Mail-out" Laboratory
6240 RCP
356-3527
Specimen:
Whole Blood
Collection Medium:
Lavender top tube (EDTA)
Alternate
Collection Media:
Yellow top tube (ACD solution B)
Minimum:
Adult preferred minimum:  5 mL whole blood in EDTA tube
Pediatric(0-4 years) minimum: 3 mL whole blood in EDTA tube
Rejection Criteria:
Specimens collected in green top (heparin) tubes; do not collect on 
Fridays, holidays, day before a holiday, or weekends.
Analytic Time:
7 working days
Reference Range:
By Report
The following HLA combinations are associated with narcolepsy:
DRB1*15 negative; DQB1*0602 positive
DRB1*15 positive; DQB1*0602 negative
DRB1*15 positive; DQB1*0602 positive
The value of HLA typing in patient suspected of having an HLA 
associated disease depends on a presumptive diagnosis of the disease 
based on clinical and other laboratory findings.  The presence of a 
particular HLA antigen does not establish the diagnosis of any 
particular disease but provides a probability statement for the 
existence of the disease in the patient.
This test is performed pursuant to an agreement with Roche Molecular 
Systems, Inc.
Comments:
Can be refrigerated for one week.
Methodology:
Polymerase Chain Reaction (PCR)
CPT Code:
83891, 83894(x2), 83900(x2), 83912; additional CPT codes modifiers may 
be required for procedures performed to test for oncologic or inherited 
disorders.

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Updated: 08/19/2009

Note: The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.