Xing Laboratory of RNA Genomics and Bioinformatics

Publications

Submitted  
  • 38. Monteys AM., Spengler RM., Wan J., Tecedor L., Lennox KA., Xing Y., Davidson BL. (2009) Structure and activity of putative intronic miRNAs promoters. RNA, under revision.

  • 2009  
  • 37. Shen S., Warzecha CC., Carstens RP., Xing Y. (2009) MADS+: discovery of differential splicing events from Affymetrix exon junction array data. Bioinformatics, to appear.
  • 36. Lin CL., Evans V., Shen S., Xing Y., Richter JD. (2009) The nuclear experience of CPEB: implications for RNA processing and translational control. RNA, to appear.
  • 35. Lu H., Lin L., Sato S., Xing Y., Lee CJ. (2009) Predicting functional alternative splicing by measuring RNA selection pressure from multigenome alignments. PLoS Computational Biology, to appear.
  • 34. Borchert GM., Gilmore BL., Spengler RM., Xing Y., Lanier W., Bhattacharya D., Davidson BL. (2009) Adenosine deamination in human transcripts generates novel microRNA binding sites. Human Molecular Genetics, in press. [journal]
  • 33. Warzecha CC., Shen S., Xing Y., Carstens RP. (2009) The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. RNA Biology, in press. [journal]
  • 32. Lin L.*, Liu S.*, Brockway H., Seok J., Jiang P., Wong WH., Xing Y. (2009) Using high-density exon arrays to profile gene expression in closely related species. Nucleic Acids Research, 12: e90 (*joint first authors). [journal][Supplemental Data] [JETTA software]
  • 31. Lin L., Jiang P., Shen S., Sato S., Davidson BL., Xing Y. (2009) Large-scale analysis of exonized mammalian-wide interspersed repeats (MIRs) in primate genomes. Human Molecular Genetics. 18: 2204-2214 [journal] [pdf]
  • 30. Boudreau R., McBride J., Martins I., Shen S., Xing, Y., Carter B., Davidson, BL. (2009) Non-allele-specific silencing of mutant and wildtype huntingtin demonstrates therapeutic efficacy in Huntington's disease mice. Molecular Therapy. 17:1053-1063 [journal][pdf]

  • 2008  
  • 29. Packer, AN., Xing, Y., Harper SQ., Jones, L., Davidson, BL. (2008) The bi-functional microRNA miR-9/miR-9* regulates REST and CoREST and is down-regulated in Huntington's Disease. Journal of Neuroscience. 28: 14341-14346 [journal] [pdf] [This Week in the Journal of Neuroscience].
  • 28. Lin, L., Shen, S., Tye, A., Cai, JJ., Jiang, P., Davidson, BL., Xing, Y. (2008) Diverse splicing patterns of exonized Alu elements in human tissues. PLoS Genetics. 4(10):e1000225. [journal] [UI news release] [GenomeWeb Daily News] [News and Commentary at Heredity] [Supplemental Data]
  • 27. Kapur, K., Jiang, H., Xing, Y., Wong, WH. (2008) Cross-hybridization modeling on Affymetrix Exon Arrays. Bioinformatics. 24: 2887-2893 [software] [journal] [pdf]
  • 26. Roy, M., Kim, N., Xing, Y., Lee, C. (2008) The effect of intron length on exon creation ratios during evolution of mammalian genomes. RNA. 14: 2261-2273 [journal] [pdf]
  • 25. Xing, Y.*, Stoilov, P., Kapur, K., Han, A., Jiang, H., Shen, S., Black, DL., Wong, WH*. (2008) MADS: a New and Improved Method for Analysis of Differential Alternative Splicing by Exon-tiling Microarrays. RNA.14(8):1470-1479 (* joint corresponding authors). [journal] [pdf] [dataset] [software]
  • 24. Chiao, E, Elezar, M, Xing, Y.,Xiong, A., Kmet, M., Millan, M., Glenn, J., Wong, WH., Baker, J. (2008) Isolation and Transcriptional Profiling of Purified Hepatic Cells Derived from Human Embryonic Stem Cells. Stem Cells, 26(8):2032-2041.. [journal] [pdf]
  • 23. Cahoy, J., Emery, B., Kaushal, A., Foo, L., Zamanian, J., Christopherson, K., Xing, Y., Lubischer, J., Krieg, P., Krupenko, S., Thompson, W. and Barres, B. (2008) A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function. Journal of Neuroscience. 28(1):264-278. [journal] [pdf] [This Week in the Journal of Neuroscience] [faculty of 1000 Must Read]

  • 2007  
  • 22. Calarco, JA.*, Xing, Y.*, Caceres, M.*, Calarco, JP., Xiao, X., Pan, Q., Lee, C., Preuss, T. and Blencowe, B. (2007) Global analysis of alternative splicing differences between humans and chimpanzees. Genes and Development. 21:2963-2975. (* joint first authors). [journal] [pdf] [news report] [highlight by Cell]
  • 21. Xing, Y. *, Ouyang, Z., Kapur, K., Scott, MP., Wong, WH*. (2007) Assessing the conservation of mammalian gene expression using high-density Exon Arrays. Molecular Biology and Evolution. 24(6):1-3. (* joint corresponding authors). [journal] [pdf] [dataset]
  • 20. Kapur, K., Xing, Y., Ouyang, Z., Wong, WH. (2007) Exon arrays provide accurate assessments of gene expression. Genome Biology. 8:R82. [journal] [pdf] [software]
  • 19. Xing, Y. (2007) Genomic analysis of alternative splicing in cancers. Frontiers in Biosciences. 12:4034-4041. [journal] [pdf]
  • 18. Parker, DS., Hsiao, RL., Xing, Y., Resch, A., Lee, C. (2007) Solving the problem of trans-genomic query with alignment tables. IEEE Transactions on Computational Biology and Bioinformatics. 2007:1073. [pdf]
  • 17. Lee , JA., Xing, Y., Nguyen, D., Xie, J., Lee, C., Black, DL. (2007) Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements. PLoS Biology. 5(2):e40. [journal] [pdf]

  • 2006  
  • 16. Xing, Y., Kapur, K., Wong, WH. (2006) Probe selection and expression index computation of Affymetrix Exon Arrays. PLoS ONE. 1(1):e88. [journal] [pdf] [software]
  • 15. Xing,Y. *#, Yu,T. *, Wu, Y., Roy, M., Kim, J., Lee,C.# (2006) An expectation-maximization algorithm for probabilistic reconstruction of full-length isoforms from splice graphs. Nucleic Acids Research. 34:3150-3160 (# joint corresponding authors; * joint first authors). [journal] [pdf] [source code]
  • 14. Xing,Y., Wang, Q., Lee,C. (2006) Evolutionary divergence of exon flanks: A dissection of mutability and selection. Genetics. 173(3):1787-91. [journal] [pdf]
  • 13. Xing, Y., Lee, C. (2006) Alternative splicing and RNA selection pressure: evolutionary consequences for eukaryotic genomes. Nature Reviews Genetics. 7:499-509. [journal] [pdf]
  • 12. Xing,Y., Lee,C. (2006) Can RNA selection pressure distort the measurement of Ka/Ks? Gene. 370:1-5. [journal] [pdf]

  • 2005  
  • 11. Xing,Y., Lee,C. (2005) Protein modularity of alternatively spliced exons is associated with tissue-specific regulation of alternative splicing. PLoS Genetics. 1(3):e34. [journal] [pdf]
  • 10. Xing,Y., Lee,C. (2005) Evidence of functional selection pressure for alternative splicing events that accelerate evolution of protein subsequences. Proc. Natl. Acad. Sci. U.S.A. 102:13526-13531.[journal] [pdf]
  • 9. Xing,Y., Lee,C. (2005) Assessing the application of Ka/Ks ratio test to alternatively spliced exons. Bioinformatics. 21: 3701-3703. [journal] [pdf]

  • 2004  
  • 8. Resch,A., Xing, Y., Alekseyenko, A., Modrek, B., Lee, C. (2004) Evidence for a subpopulation of conserved alternative splicing events under selection pressure for protein reading frame preservation. Nucleic Acids Research. 32:1261-9. [journal] [pdf]
  • 7. Xing,Y., Lee,C. (2004) Negative selection pressure against premature protein truncation is reduced by alternative splicing and diploidy. Trends in Genetics. 20:472-5. [journal] [pdf]
  • 6. Resch,A., Xing,Y., Modrek,B.,Gorlick,M., Riley,R., Lee, C. (2004) Assessing the impact of alternative splicing on domain interactions in the human proteome. Journal of Proteome Research. 3:76-83. [journal] [pdf]
  • 5. Xing,Y., Resch,A.,Lee,C. (2004) The multiassembly problem: reconstructing multiple transcript isoforms from EST fragment mixtures. Genome Research. 14(3):426-4. [journal] [pdf] [database]
  • 4. Grasso,C.,Modrek,B.,Xing,Y., Lee,C. (2004) Genome-wide detection of alternative splicing in expressed sequences using partial order multiple sequence alignment graphs. Pac. Symp. Biocomputing. World Scientific: Singapore 29-41. [pdf]

  • 2003  
  • 3. Zewail,A.*, Xie, M.W.*, Xing, Y., Lin, L., Zhang, P.F., Zou, W., Saxe, J.P., and Huang, J. (2003) Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin. Proc. Natl. Acad. Sci. U.S.A. 100: 3345-3350. [journal] [pdf]
  • 2. Xing,Y., Xu, Q, Lee,C. (2003) Widespread production of novel soluble protein isoforms by alternative splicing removal of transmembrane anchoring domains. FEBS Letters. 555(3):572-8. [journal] [pdf]
  • 1. Lee C, Atanelov L, Modrek B, Xing Y. (2003) ASAP: the Alternative Splicing Annotation Project. Nucleic Acids Research. 31(1):101-5. [journal] [pdf]