Nitin Karandikar Laboratory—Department of Pathology

  • Selected Publications

    1. Tyler AF, Mendoza JP, Firan M and Karandikar NJ. CD8+ T cells are required for glatiramer acetate therapy in autoimmune demyelinating disease. Jun 21;8(6):e66772, PLoS One, 2013.
    2. Ortega SB, Kashi, VP, Tyler AF, Cunnusamy K, Mendoza JP and Karandikar NJ . The disease-ameliorating function of autoregulatory CD8 T-cells is mediated by targeting of encephalitogenic CD4 T-cells in EAE. Jul 1;191(1):117-26, Journal of Immunology, 2013.
    3. Ayers CL, Mendoza JP, Sinha S, Cunnusamy K, Greenberg BM, Frohman EM, Karandikar NJ., Modulation of immune function occurs within hours of therapy initiation for multiple sclerosis. May;147(2):105-19, Clinical Immunology, 2013.
    4. Gutierrez T, Mayeux JM, Ortega SB, Karandikar NJ, Li QZ, Rakheja D, Zhou XJ, Satterthwaite AB. IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice. Feb;43(2):382-93, Eur J Immunol. 2013.
    5. Greenberg BM, Graves D, Remington G, Hardeman P, Mann M, Karandikar N, Stuve O, Monson N, Frohman E. Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success. Jul;18(7):1022-6, Multiple Sclerosis, 2012.
    6. Greenberg, B.M., Graves D, Remington G, Hardeman P, Mann M, Karandikar N, Stuve O, Monson N, Frohman E. Rituximab dosing and monitoring strategies in neuromyelitis optica patients: creating strategies for therapeutic success. Multiple Sclerosis (2012) In Press.
    7. Biegler, B.W., S.X. Yan, S.B. Ortega, D.K. Tennakoon, M.K. Racke and N.J. Karandikar. Clonal Composition of Neuroantigen-specific CD8+ and CD4+ T-cells in Multiple Sclerosis. J. Neuroimmunology (2011) 234: 131-40.
    8. Baughman, E.J., J.P. Mendoza, S.B. Ortega, C.L. Ayers, B.M. Greenberg, E.M. Frohman and N.J. Karandikar. Neuroantigen-Specific CD8+ Regulatory T-cell Function is Deficient During Acute Exacerbation of Multiple Sclerosis. J. Autoimmunity (2011) 36: 115-24.
    9. Ayers, C.L., M. Firan, V. Pillai, W.M. Lee and N.J. Karandikar. Viral Interactions With B-cells Contribute to Increased Regulatory T-cells During Chronic HCV Infection. Viral Immunology (2011) 24:119-29.
    10. York, N.R., J.P. Mendoza, S.B. Ortega, A. Benagh, A.F. Tyler, M. Firan and N.J. Karandikar. Immune regulatory CNS-reactive CD8+ T cells in experimental autoimmune encephalomyelitis. Journal of Autoimmunity (2010) 35: 33-44.
    11. Chen Y., H. Wu, H. Koito, J. Li, J. Hoang, S. Wang, S.S. Escobar, Alex Gow, Heather A. Arnett, Bruce D. Trapp, N.J. Karandikar, J. Hsieh and Q.R. Lu. The oligodendrocyte-specific G-protein coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nature Neuroscience (2009) 12:1398-406.
    12. Olteanu H., H-Y Wang, W. Chen, R.W. McKenna and N.J. Karandikar. Immunophenotypic studies of monoclonal gammopathy of undetermined significance. BMC Clinical Pathology (2008) 8:13.
    13. Pillai, V. and N.J. Karandikar. Attack on the Clones?: Human FOXP3 detection by PCH101, 236A/E7, 206D and 259D reveals 259D as the outlier with lower sensitivity Blood (2008) 111:463-4.
    14. Wang, H-Y., K.S. Wilson, R.W. McKenna, Y. Xu, D. Payne and N. Karandikar. An Extranodal Nasal Natural Killer / T-cell Lymphoma With Isochromosome 7q10 As the Sole Cytogenetic Aberration Was Initially Diagnosed via Bone Marrow Biopsy. Archives of Pathology and Lab Medicine (2007) 131:1709-14.
    15. Sathe, A., S.B. Ortega, D.I. Mundy, R.H. Collins and N.J. Karandikar. In vitro methotrexate as a practical approach to selective allodepletion. Biology of Bone Marrow Transplantation (2007) 13:644-54.
    16. Pillai, V., W.M. Lee, D.L. Thiele and N.J. Karandikar. Clinical Responders to Antiviral Therapy of Chronic HCV Infection Show Elevated Antiviral CD4+ and CD8+ T-cell Responses. Journal of Viral Hepatitis (2007) 14:318-29.
    17. Averill, L., W.M. Lee and N.J. Karandikar. Differential dysfunction in dendritic cell subsets during chronic HCV infection. Clinical Immunology (2007). 123:40-9.
    18. Pillai, V., S.B. Ortega, C.K. Wang and N.J. Karandikar. Transient Regulatory T-cells: A State Attained by All Activated Human T-cells. Clinical Immunology (2007). 123:18-29.
    19. Seegmiller, A.C., Y. Xu, R.W. McKenna and N.J. Karandikar. Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs. plasma cell myeloma. American Journal of Clinical Pathology (2007) 127:176-181.
    20. Biegler, B.W., S.X. Yan, S.B. Ortega, D.K. Tennakoon, M.K. Racke and N.J. Karandikar. Glatiramer acetate (GA) therapy induces a focused, oligoclonal CD8+ T-cell repertoire in multiple sclerosis. Journal of Neuroimmunology (2006) 180:159-71.
    21. Ratts, R.B., N.J. Karandikar, A.E. Lovett-Racke, J. Choy, S.C. Northrop, R.Z. Hussain and M.K. Racke. Phenotypic characterization of autoreactive T cells in multiple sclerosis. Journal of Neuroimmunology (2006) 178:100-10.
    22. Ratts, R.B., A.E. Lovett-Racke, J. Choy, S.C. Northrop, R.Z. Hussain, N.J. Karandikar and M.K. Racke. CD28(-)CD57(+) T cells predominate in CD8 responses to glatiramer acetate. Journal of Neuroimmunology (2006) 178:117-29.
    23. Tennakoon, D.K., R.S. Mehta, S.B. Ortega, V. Bhoj, M.K. Racke and N.J. Karandikar. Therapeutic induction of regulatory, cytotoxic CD8+ T cells in multiple sclerosis. Journal of Immunology. (2006) 176:7119-29.
    24. Karandikar, N.J., S.H. Kroft, S. Yegappan, B.B. Rogers, V.M. Aquino, K. Lee, V. Kumar, F.J. Guenaga, E.S. Jaffe, D.C. Douek and R.W. McKenna. Unusual immunophenotype of CD8+ T-cells in familial hemophagocytic lymphohistiocytosis. Blood (2004). 107(7): 2007-9.
    25. Kroft, S.H., S.L. Asplund, R.W. McKenna, and N.J. Karandikar. Hematogones in the Peripheral Blood of Adults: A Four-Color Flow Cytometry Study of 102 Patients. British Journal of Haematology (2004). 126: 209-12.
    26. Crawford, M.P., S.X. Yan, S. Ortega, R.S. Mehta, R.E. Hewitt, D.A. Price, P. Stastny, D.C. Douek, R.A. Koup, M.K. Racke, and N.J. Karandikar. High prevalence of autoreactive neuroantigen-specific CD8+ T Cells in multiple sclerosis revealed by novel flow cytometric assay. Blood (2004) 103: 4222-31.
    27. Brenchley, J.M., N.J. Karandikar, M.R. Betts, D.R. Ambrozak, B.J. Hill, L.E. Crotty, J.P. Casazza, J. Kuruppu, S.A. Migueles, M. Connors, M. Roederer, D.C. Douek, and R.A. Koup. Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T-cells. Blood (2003) 101: 2711-2720.
    28. Karandikar, N.J., M.P. Crawford, X. Yan, R.B. Ratts, J.M. Brenchley, D.R. Ambrozak, A.E. Lovett-Racke, E.M. Frohman, P. Stastny, D.C. Douek, R.A. Koup, and M.K. Racke. Glatiramer acetate (Copaxone®) induces CD8+ T-cell responses in patients with multiple sclerosis. Journal of Clinical Investigation (2002) 109: 641-9.
    29. Karandikar, N.J., E.C. Hotchkiss, R.W. McKenna and S.H. Kroft. Transient stress lymphocytosis: an immunophenotypic characterization of the most common cause of newly identified adult lymphocytosis in a tertiary hospital. American Journal of Clinical Pathology (2002) 117:819-25.
    30. Karandikar, N.J., D.B. Aquino, R.W. McKenna and S.H. Kroft. Transient myeloproliferative disorder and acute myeloid leukemia in Down syndrome: An immunophenotypic analysis. American Journal of Clinical Pathology (2001) 116: 204-210.
    31. Karandikar, N.J., T.N. Eagar, C.L. Vanderlugt, J.A. Bluestone, and S.D. Miller. CTLA-4 downregulates epitope spreading and mediates remission in autoimmune disease. Journal of Neuroimmunology (2000) 109: 173-180.
    32. Karandikar, N.J., C.L. Vanderlugt, T. Eagar, L.J. Tan, J.A. Bluestone, and S.D. Miller. Tissue-specific up-regulation of B7-1 expression and function during the course of murine relapsing experimental autoimmune encephalomyelitis. Journal of Immunology (1998) 161: 192-199.
    33. Karandikar, N.J.*, B.L. McRae*, and S.D. Miller. Degenerate antigen recognition by CD4+ effector T cells in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology (1997) 75: 156-162. (*co-first authors)
    34. Karandikar, N.J., C.L. Vanderlugt, T.L. Walunas, S.D. Miller, and J.A. Bluestone. CTLA-4: A negative regulator of autoimmune disease. Journal of Experimental Medicine (1996) 184: 783-788.
    35. Miller, S.D., C.L. Vanderlugt, D.J. Lenschow, J.G. Pope, N.J. Karandikar, M.C. Dal Canto, and J.A. Bluestone. Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE. Immunity (1995) 3: 739-745.