Iowa Institute of Human Genetics

  • Iowa Institute of Human Genetics (IIHG) Grant Application Instructions

    Deadline (Extended):  November 29, 2013

    Please note:  We encourage you to submit an application by November 29th, although the IIHG is currently evaluating the merits of the program. Under consideration are whether the program should be continued and if so, at what level of funding.

    Application Form

    Purpose, Policies, Information and Instructions

    The Iowa Institute of Human Genetics (IIHG) at the University of Iowa is accepting applications for pilot grants in human genetics. Awards up to $50,000 for one year will be funded to investigators in the State of Iowa. Projects MUST be focused on human genetics. Ideally the grant should generate preliminary data for larger projects with the goal of obtaining external funding.

    I. PURPOSE

    The purpose of the IIHG pilot grant program is to encourage and support research in HUMAN GENETICS. Appropriate areas of research include basic human genetics, genome biology, computational genetics, model organisms of human genetic disease, translational studies of human genetic disease, human disease gene mapping/gene identification, gene vs environment studies in human disease, pharmacogenomics, epidemiology/human population genetics, statistical genetics, or ethical issues of human genetics. Collaborations between investigators from different colleges are encouraged.

    II. POLICIES

    A. PUBLICATION, PRESENATION, AND GRANT POLICY.

    Investigators must provide a plan for how preliminary data can be used to apply for a larger external grant. Individuals awarded grants MUST present at Grand Rounds or Departmental Seminars at their home department as a demonstration of how human genetics is broadly applicable as a tool to many fields of study. Investigators should recognize IIHG support in publications and presentations that result from pilot grant funding.

    B. CONDITIONS OF SUPPORT.

    The project period is for one year with a beginning date of January 1. A grant may be revoked or terminated by the IIHG at any time within the project period if it is determined that the Principal Investigator has failed in a material respect to comply with the terms and conditions of the grant.  Whenever possible, the use of the IIHG Genomics and Bioinformatics Divisions is strongly encouraged.

    C. PROJECT CHANGES.

    Changes in project methodology or approach are permissible if these changes expedite achievement of the project’s research objective AND are approved in writing from the IIHG in response to a letter of request and explanation from the PI. When the PI is absent or unable to work for a period of two months or more, or wishes to withdraw from the project or to transfer to another institution, the IIHG must be notified in writing immediately. Disposition of the grant will be determined by negotiation.

    E. ACCOUNTING RECORDS AND AUDIT.

    Accounting records for the grant should be in accord with the Grantee Institution’s accounting practices. A year-end report of expenditures must be submitted to show the exact nature of expenditures within four months after the end of the grant period (see II.F.1.).

    F. REPORTS.

    1. Progress reports may be requested by the IIHG during the grant period.
    2. A Financial Report must be submitted within four months of the end of the grant period.
    3. A Research Report must be submitted within four months of the end of the grant period.

    G. QUALIFICATION AND CRITERIA FOR REVIEW.

    A research proposal will qualify for review when it involves studies related to HUMAN GENETICS. The proposal must be supported by a statement from the investigator as to how the results may be used to apply for a larger external grant. This statement is to be included under the Research Plan, 3 III.B.8.c. Collaborations between basic science and clinical departments are encouraged.

    H. HUMAN SUBJECTS AND ANIMAL RESEARCH.

    Before the proposal will be considered for review, the Institutional Review Board (IRB) and/or Institutional Animal Care and Use Committee (IACUC) of the applicant institution must review and approve the proposal. A copy of the letter(s) of approval must be attached. If approval is pending, a copy of the letter of approval must be sent no later than 30 days after the grant application deadline. Indicate "Pending" on the Face Page of the application. The policies of the Office for Protection from Research Risk (OPRR), National Institutes of Health, Bethesda, Maryland 20892 must be fully implemented and satisfied.

    III. INFORMATION AND INSTRUCTIONS FOR A RESEARCH APPLICATION

    A. GENERAL INFORMATION.

    The applicant should read the instructions in order to avoid delays and misunderstandings. Incomplete or inaccurate applications will not be reviewed. The application can be downloaded from the IIHG website at http://www.medicine.uiowa.edu/humangenetics/. The application must be prepared in English and typed in Arial 11 font, single-spaced, using standard black type. Do not include photographs, over-sized documents or materials that cannot be readily photocopied in the application. Strictly follow the page limitations set forth in the following instructions. Number the pages of the application consecutively (not 2A, 2B, etc.) at the bottom of each page, beginning with the face page of the grant. Use blank continuation pages where needed, numbering them consecutively at the bottom of the page. Electronic submissions ONLY; signed applications must be submitted to iihg@uiowa.edu.

    B. SPECIFIC INSTRUCTIONS FOR GRANT APPLICATION

    1. Face Page. State project title, name, title, and degrees of principal investigator, dates of proposed project period, and the direct, indirect, and total costs. For numbers 5-7, indicate institutional address and phone number for the principal investigator, the applicant organization, the performance site, if different.

    Non-University of Iowa Applicants:  For numbers 8-9, please indicate the official who is authorized to sign for the applicant organization (e.g., Assistant Dean for Research, etc.), and the official in the Business Office who will accept an award on behalf of the Principal Investigator.

    University of Iowa Applicants:  For number 8, please indicate institutional address and phone number for your Departmental Executive Officer (DEO)/Chair. For number 9, please indicate the Departmental Administrator to contact for MFK transfer information.

    For number 10 and number 11, indicate status of project approval by the Human Subjects or Institutional Animal Use and Care Committee.

    Non-University of Iowa Applicants:  For number 12, the Principal Investigator’s and Institutional Official’s signatures are required.

    University of Iowa Applicants:  For number 12, the Principal Investigator’s and DEO/Chair’s signatures are required.

    2. Biographical Sketch(es). Submit biographical sketches for the Principal Investigator and Coinvestigator(s) in NIH format.

    3. Budget. Present a detailed budget for the twelve-month period. Salary and travel support for investigators are NOT allowed. Justify equipment costing more than $1,000. (Additional pages may be added if necessary.)

    4,5. Human Subjects; Animals. If human subjects or animals will be used in this project, before the proposal will be considered, the Institutional Review board (IRB) or Institutional Animal Care and Use Committee (IACUC) of the applicant institution must review and approve the proposal. If approval is pending, a letter of approval must be submitted within 30 days after the grant application deadline. The policies of the Office for Protection from Research Risk (OPRR), National Institutes of Health, Bethesda, Maryland 20892 must be fully implemented and satisfied.

    6. Other Research Support. List all other current and pending research support. Use NIH format.

    7. Collaborative Arrangements. List briefly any collaborative arrangements you have made with other investigators affiliated with the University of Iowa. Collaborations between investigators from basic science and clinical departments are encouraged.

    8. Research Plan and Supporting Data. Copy this page or use blank continuation page as needed. (NOT OVER 6 PAGES TOTAL FOR a THROUGH d)

    a) Introduction, Background and Significance. Present a concise description of the background and current status of work in the area of this proposal and the rationale
    behind your approach to the problem. Mention any special or unusual ideas or contributions, which your approach offers and explain the potential importance for the
    proposed work. Emphasize your awareness of significant developments in the field by discussing pertinent literature. Cite key references to aid the IIHG in evaluating the merits of the proposal [indicate these key references by an asterisk (*)].

    b) Research Statement. INCLUDE: A paragraph statement indicating how the research may be used to apply for a larger external grant.

    c) Preliminary Studies. New applications should include PRELIMINARY STUDIES pertinent to the application. (NO MORE THAN 3 PAGES FOR SECTIONS a, b, c)

    d) Experimental Design and Methods. Give details of your research plan. Include a description of the types of experiments or other work to be performed; methods, species, and techniques to be used; the kinds of data to be obtained and the method of data analysis. (NO MORE THAN 3 PAGES)

    e) Facilities and Equipment. Describe facilities at your disposal and list major items of permanent equipment available for this research.

    f) Literature Cited.