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Research in the Harty laboratory is focused on understanding the dynamics of the T cell
response, how effector and memory T cell differentiation are regulated, how
memory T cell populations are maintained and how they can be generated and
manipulated to enhance protective immunity. We then use this basic information
to manipulate immune responses for optimal protection against Plasmodium infection of the liver and
blood and Influenza virus infection of the lung.
The major approaches in the lab involve identification
of new questions through sophisticated analyses of in vivo T
cell responses to various pathogens or immunization regimens. These
observations are then dissected at the cellular, biochemical and molecular
levels to generate a comprehensive mechanistic view of T cell regulation. We recently initiated projects to use
intravital 2-Photon imaging to further dissect immunity to infections of the liver, brain and lungs. Ultimately our
goal is to provide fundamental insights that will inform vaccine design and therapeutic interventions for major human infectious diseases.
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