Obesity Research and Education Initiative

Dr. Lyse Norian receives NIH National Cancer Institute RO1 Grant

Dr. Lyse Norian, an Assistant Professor of Urology and faculty member in the Obesity Research and Education Initiative, has been awarded a new R01 grant from the NIH National Cancer Institute. The project entitled “Obesity Affects Immunity to Kidney Cancer” is funded for five years beginning in December 2013. The objective in this project is to define the cellular and molecular basis for impaired anti-tumor immunity in obese mice and humans. The long-term goal is to identify specific immunological defects that arise in response to the combination of obesity and tumor outgrowth, then leverage this information to develop effective immunotherapies for cancer patients. In addition, the studies should reveal new obesity-related immunologic patterns that can act as predictive biomarkers for immunotherapeutic failure in patients with kidney cancer and other obesity-related cancers.