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CCOM Investigators Receive NIH “Challenge” and “GO” Grants

Published: 9/30/2009

Six Carver College of Medicine Investigators have been awarded grants as part of new “challenge” and “GO” programs offered by the National Institutes of Health. Together, the seven grants represent over $7 million in new funding.

Investigators receiving challenge grants include:

Bev Davidson, PhD, Roy J. Carver Professor in Internal Medicine
“RNA Interference Therapy for Huntington’s Disease: Studies in non-Human Primates”
“Translating CNS Therapies for the NCLS from Rodent Models to Humans”

John Engelhardt, PhD, Roy J. Carver Chair in Molecular Medicine and professor and head, anatomy and cell biology
“Pathological Evaluation of a Cystic Fibrosis Ferret Model”

Michael Henry, PhD, associate professor of physiology and biophysics and pathology
“Effects of Pesticides on Prostate Cancer Progression in PTEN Mutant Mice”

Barcey Levy, MD, PhD, professor of family medicine
“Comparative Effectiveness of FIT vs. Colonoscopy for Colon Cancer Screening”

James A. Martin, PhD, research associate professor of orthopaedic surgery
“Biomarkers of the Risk for Post-Traumatic Osteoarthritis”

Investigators receiving GO grants include:

Kevin Campbell, PhD, Roy J. Carver Chair of Biomedical Research in Molecular Medicine and professor and head, physiology and biophysics
“High-Throughput Genetic and Small Molecule Screening for Therapeutic Modifiers”


The newly-established challenge grant program was created with funds from the American Recovery and Reinvestment Act of 2009 (ARRA) to support research on ‘challenge topics’ outlined by the NIH (listed below).

The GO, or grand opportunities grant program was also established in 2009 with ARRA funds. The GO program supports projects that address large, high-impact, biomedical and biobehavioral research endeavors. Research projects funded as part of the program are are large-scale and accelerate critical breakthroughs, early and applied research on cutting-edge technologies and new approaches to improve the interactions among multi and interdisciplinary research teams.

Both programs were established through the ARRA to focus on specific knowledge gaps, scientific opportunities, new technologies, data generation or research methods that would benefit from an influx of funds to advance the research area in a significant way. Challenge and GO award recipients receive funding for 2 years.

NIH Challenge Areas

*Behavior, Behavioral Change, and Prevention
*Bioethics
*Biomarker Discovery and Validation
*Clinical Research
*Comparative Effectiveness Research
*Enabling Technologies
*Enhancing Clinical Trials
*Genomics
*Health Disparities
*Information Technology for Processing Health Care Data
*Regenerative Medicine
Science, Technology, *Engineering and Mathematics Education (STEM)
*Smart Biomaterials - Theranostics
*Stem Cells
*Translational Medicine

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